● In Stock
Melanotan II
≥99% Purity | HPLC Verified
$45.00
PASSED
Sterility & Endotoxins
PASSED
Net Content & Purity
Purity:
≥99%
Store at
-20°C
Cyclic heptapeptide melanocortin agonist studied for pigmentation and sexual function in preclinical research. Research use only.
| Strength | 10mg |
| molecular_formula | C50H69N15O9 |
| Molecular Weight | 1024.18 g/mol |
| Purity | >99% (HPLC) |
| Form | Lyophilized Powder |
85%
Erectile Response
17/20 subjects vs 3/20 placebo
100%
Melanin Increase
Active group, Barnetson RCT 2006
No UV
Tanning Required
UV-independent pigmentation
4
Receptor Types
MC1R, MC3R, MC4R, MC5R
Mechanism of Action
How Melanotan II Works
Multi-receptor melanocortin agonist — pigmentation, sexual function, and metabolic pathways via distinct receptor subtypes
MC1R
MC1R — Pigmentation
Binds melanocortin-1 receptors on melanocytes, activating cAMP-PKA signaling to stimulate eumelanin synthesis — even in MC1R variant carriers who cannot normally tan
MC4R
MC4R — Sexual Function
Central nervous system activation via hypothalamic MC4R produces pro-erectile effects and appetite suppression — the basis for PT-141 (bremelanotide) development
MC3
MC3R / MC5R — Metabolic
Moderate affinity for MC3R and MC5R modulates energy homeostasis and exocrine gland function, contributing to appetite reduction and metabolic effects
α-MSH Analog
Non-Selective Melanocortin Agonist
Cyclic heptapeptide with higher receptor affinity than native α-MSH — activates 4 of 5 melanocortin receptors
High
MC1R Affinity (Tanning)
High
MC4R Affinity (Sexual)
Mod
MC3R (Metabolism)
Mod
MC5R (Exocrine)
Clinical Research
What Research Has Shown
Randomized controlled trial data on tanning, sexual function, and melanocortin receptor pharmacology
85%
Primary Endpoint
Erectile Response Rate
Double-blind RCT · 20 subjects · Wessells et al. 1998 · PMID 9679884
Tanning & Pigmentation Results
MT-II vs Placebo (Wessells 1998)
Common Side Effects (Dose-Dependent)
Side effects typically diminish with continued use. Dose-dependent.
🔮
Research Applications
Documented effects from controlled studies across melanocortin receptor subtypes
🌞 Tanning Mechanism
MC1R-cAMP-PKA Cascade
MT-II activates MC1R, driving the same intracellular pathway UV radiation triggers — without sun exposure
Key finding: MT-II induced tanning even in subjects with MC1R variant alleles who typically cannot tan from UV exposure alone. (Barnetson 2006)
⚡ Erectile Function
Central MC4R Activation
Hypothalamic pathway driving pro-erectile response — mechanism that led to PT-141 development
Response rate (MT-II)85% (17/20)
Response rate (placebo)15% (3/20)
Mean tip rigidity >80%Confirmed
Mean duration~40 min
Statistical significanceP<0.001
⚠️ Safety Considerations
Monitoring & Risk Factors
Key items for clinical observation during research
Mole/nevus changesMonitor closely
Priapism (>4 hrs)Seek care
Blood pressureMonitor
Nausea (most common)40%, transient
FDA approval statusNot approved
Note: Both MT-II and PT-141 are banned by WADA (S0). Neither is approved for human therapeutic use.
Compound Specifications
Compound Information
Chemical and structural properties of Melanotan II
Molecular Profile
Melanotan II Structure
CAS Number121062-08-6
Molecular FormulaC50H69N15O9
Molecular Weight1,024.18 g/mol
Amino Acids7 (cyclic heptapeptide)
SequenceAc-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Structure typeCyclic lactam
Receptor Binding
Melanocortin Receptor Affinity
MC1RHigh affinity — Pigmentation
MC3RModerate — Metabolism
MC4RHigh affinity — Sexual function
MC5RModerate — Exocrine
vs native α-MSHGreater potency + duration
Related compoundPT-141 (MC4R selective)
Research onlyWADA banned S0
Storage & Status
Formulation & Regulatory
AppearanceWhite lyophilized powder
Storage2–8°C (refrigerated)
Reconstituted stability30 days refrigerated
SolubilityWater, saline
FDA statusNot approved
WADA statusBanned (S0, since 2022)
Scientific Literature
Key Publications
Peer-reviewed clinical and preclinical studies on Melanotan II
- Barnetson RS, et al. Self-administration of a melanocyte-stimulating hormone analogue for skin cancer photoprotection. J Invest Dermatol. 2006;126(9):1974-80. PMID: 16293341.
- Wessells H, et al. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urology. 1998;160(2):389-93. PMID: 9679884.
- Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sciences. 1996;58(20):1777-84. PMID: 8831529.
- Hadley ME, et al. Biological activities of melanotropic peptide fatty acid conjugates. Proc Natl Acad Sci. 1985;82(18):6157-60. PMID: 4041450.
Common Questions
Frequently Asked Questions
Common questions about Melanotan II research
Melanotan II activates MC1R receptors on melanocytes, triggering the same intracellular signaling cascade (cAMP-PKA pathway) that UV light activates. This stimulates eumelanin synthesis directly, bypassing the need for UV-induced DNA damage that normally initiates the tanning response. The 2006 randomized controlled trial showed this works even in individuals with MC1R genetic variants who typically cannot tan from UV exposure.
Melanotan I (afamelanotide) is a linear 13-amino acid peptide that primarily targets MC1R for pigmentation with minimal sexual side effects. Melanotan II is a cyclic 7-amino acid peptide with high affinity for both MC1R (pigmentation) and MC4R (sexual function), producing both tanning and pro-erectile effects. Melanotan I has been developed as a prescription drug (Scenesse) for erythropoietic protoporphyria, while MT-II remains a research compound.
PT-141 (bremelanotide) was developed from Melanotan II by modifying the structure to reduce pigmentation effects while preserving sexual function. PT-141 primarily targets MC4R with minimal MC1R activity, so it doesn't cause tanning. PT-141 received FDA approval in 2019 for hypoactive sexual desire disorder in women, making it the only melanocortin peptide approved for sexual dysfunction.
Acute effects (nausea, flushing, appetite suppression) appear within 1–2 hours. Erectile effects begin within 30–60 minutes and may last 4–6 hours. Pigmentation effects are cumulative, typically becoming noticeable after 5–7 days of regular dosing, with full effects developing over 2–3 weeks. Pigmentation persists for weeks to months after discontinuation.
Key monitoring includes: regular dermatological examination for mole changes (darkening, new moles, irregular borders), blood pressure monitoring, assessment of nausea and tolerance, and for males, monitoring for prolonged erection (priapism >4 hours requires immediate medical attention). Cardiovascular monitoring is recommended at higher doses. Neither MT-II nor PT-141 is approved for human use.
Published research on this compound is available through PubMed and other scientific databases.
Certificate of Analysis
| Analysis Date: | Available on request |
| Lot Number: | Batch-specific |
| Purity: | >99% (HPLC) |
Third-Party Testing
- ✓ Identity verification (Mass Spectrometry)
- ✓ Purity analysis (HPLC)
- ✓ Sterility testing
- ✓ Endotoxin screening
Storage Conditions
- Lyophilized: Store at -20°C, protected from light
- Reconstituted: Store at 2-8°C, use within 30 days
- Stability: 24 months from manufacture date when stored properly
Handling Guidelines
- Use sterile technique when reconstituting
- Allow vial to reach room temperature before opening
- Reconstitute with bacteriostatic water or sterile saline
- Avoid repeated freeze-thaw cycles
RESEARCH INSIGHTS
3D Structure
Melanotan II
This compound has been extensively studied in peer-reviewed literature. Eon Peptides provides this product exclusively for legitimate in-vitro research and analytical applications.
- • High-purity research compound
- • Full analytical documentation included
- • Third-party verification available
PRODUCT SPECIFICATIONS
LOT DATA
| Lot Number | Assigned on shipment |
| Verified Purity | >99% |
| Quantity | 5mg |
MOLECULAR DATA
| Molecular Formula | Available on request |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
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These products are intended for laboratory research purposes only, and are not for human or animal consumption.